With Two BCMA-Targeting Myeloma Treatments, Which Should Be First Choice?
Experts Weigh In On Positioning BMS/Bluebird’s Abecma And GSK’s Blenrep
Market Snapshot: GSK's Blenrep and BMS's Abecma are the first of many drugs for the late-line setting. In many cases, the CAR-T may be the first choice, but some patients are unable to handle it or risk progressing while awaiting treatment.
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Idecabtagene vicleucel for fifth-line multiple myeloma lags GSK’s BCMA-targeting ADC Blenrep, but it is months ahead of J&J/Legend’s CAR-T. Abecma is BMS’s second CAR-T approval this year.
US FDA-approved belantamab mafodotin is indicated for heavily pre-treated multiple myeloma and has a list price of $23,900 per month. Its REMS could limit initial uptake, but response rates have been encouraging.
The partnership helps close the gap between Nkarta and Fate Therapeutics in terms of the breadth of their pipelines.