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Featured Stories

Get Ready For The Return Of The Mega-Merger, Leerink Says

Following tax reform, analysts expect imminent biopharma mega-mergers, with Pfizer, Merck and Roche looking to buy, AstraZeneca, Bristol and Vertex looming as take-out candidates, and Amgen as either a buyer or a target.

M & A Business Strategies Commercial

Lundbeck Snaps Up Parkinson's Developer Prexton In Deal Worth €905m

Lundbeck has swooped in to buy Merck KGaA spinout Prexton Therapeutics for €100m upfront, prior to Phase II data readouts for its potential first-in-class Parkinson's drug, foliglurax.

M & A Deals Neurology

Exelixis Eyes Liver Cancer OK To Help Drive Cabometyx Sales

Exelixis is looking to get its kidney cancer drug Cabometyx approved for hepatocellular carcinoma as well, but the therapy's long-term success is reliant on combinations with checkpoint inhibitors

Cancer Drug Review FDA

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Finance Watch: Despite Bad News, IPOs And Public Offerings Keep Flowing

Solid Biosciences was able to launch an IPO earlier this year despite a last minute disclosure about a partial clinical hold, which is now a full clinical hold that's cost investors money. Even so, Arcus Biosciences was able to launch its IPO. Ideaya, JW lead recent VC financings.

Financing Business Strategies StartUps and SMEs

PsiOxus Pursues CAR-T Mirror Image Strategy Into Clinic

Bankrolled by upfront and milestone payments associated with deals it has with Bristol-Myers Squibb, Oxford, UK-based gene therapy company PsiOxus Therapeutics is targeting two INDs in 2018 and two in 2019. Company CEO John Beadle outlined his near term plans for the unpartnered programs to Scrip during the 2018 Biotech Showcase.

StartUps and SMEs Cancer BioPharmaceutical

Alzheon IPO To Fund New Phase III Trialling Of Failed Alzheimer's Drug

Alzheon tells prospective investors it believes beta-amyloid blocker ALZ-801 can succeed in pivotal trials by treating APOE4 subgroup.

Analysis Clinical Trials

AI Drug Developer TwoXAR Raises $10m In Series A

Californian biopharma, TwoXAR, which is using a computational platform to identify drug candidates, de-risks opportunities through preclinical studies, and progresses drug candidates into the clinic, has raised $10m through a series A financing round.

Financing Artificial Intelligence

Arix Says Latest Equity Raising May Be Last For Some Time As Exit Options Loom

Arix Bioscience's £87m equity raising brings to £250m the amount it has raised for incubating life sciences start-ups – but it might be the last for a while if portfolio 'exits' start generating cash, its CEO tells Scrip.

Analysis Business Strategies

After Bad Data Comes Layoffs – Will The Next Job Cuts Be At Anthera?

Anthera is exploring strategic alternatives after its lead drug candidate Sollpura failed in Phase III, which means layoffs may be coming soon. Several other biopharma companies have had to turn to job cuts already this year.

Business Strategies Clinical Trials

Deal Watch: Ionis Turns To Affiliate Akcea In Amyloidosis

Biohaven restructures its migraine partnership with Bristol to reduce its downstream royalty commitments. Meanwhile, the pharma partners with GRYT Health's cancer app for patient/caregiver insights into cancer therapy.

Deals M & A

Diurnal's £11m Placing To Promote First Product Launch And Pipeline

Diurnal's CEO Martin Whitaker says 2018 promises to be transformational for the late-stage endocrinology company.

Financing Business Strategies

Policy & Regulation Explore this Topic

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FDA's Gottlieb: 'Pricing And Reimbursement Mischief' Holding Back Biosimilar Market

The FDA Commissioner called on payers to take steps to build the US biosimilar market and discouraged some early contracting schemes, calling them pay-for-delay tactics "dressed in the guise of rebates" in a notable speech at AHIP.

Biosimilars Pricing Debate FDA

Theratechnologies Sets $118k Yearly Price For HIV Biologic Trogarzo

The company's monoclonal antibody for multidrug resistant HIV-1 patients licensed from TaiMed will launch soon.

Approvals Pricing Strategies

AZ Sees A Future For Forxiga In Type 1 Diabetes

The EMA is looking at a marketing authorization variation for the type 2 diabetes blockbuster SGLT-2 inhibitor for use as an oral adjunct treatment to insulin in adults with type 1. Observers will be interested to see what stance the agency takes on the slightly higher number of diabetic ketoacidosis events seen in trials supporting the submission.

Metabolic Disorders Drug Review

US IP Index Based On 'Flawed' Assumptions, Claim Indian Pharma Firms

Indian drug makers have blasted the US Chamber of Commerce’s Global Innovation Policy Center over its International IP Index, saying its compilation is based on a “flawed” assumption that stronger patents drive greater innovation, and that it ignores individual national concerns.

India Policy & Regulation

Research & Development Explore this Topic

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Adaptimmune Hits High With TCR Platform Success With GSK Licensed Product

The T-cell therapy company has been tipped as a potential leader in a potentially disruptive field as new data support wide application in cancer.

Clinical Trials Cancer Research & Development

Cidara To Take Rezafungin Into Phase III In Two Severe Infection Indications

Two-week treatment data comparing the investigational echinocandin antifungal with caspofungin shows trend toward better cure rate with similar efficacy. Cidara plans Phase III trials for treatment and prevention of difficult-to-treat infections.
Research & Development Infectious Diseases

Alzheon IPO To Fund New Phase III Trialling Of Failed Alzheimer's Drug

Alzheon tells prospective investors it believes beta-amyloid blocker ALZ-801 can succeed in pivotal trials by treating APOE4 subgroup.

Analysis Clinical Trials

Excitement Over MS Stem Cell Transplant 'Game Changer' Data

An international trial has demonstrated that HSCT was more effective than standard drugs for people with highly active relapsing-remitting multiple sclerosis. Also a one-off transplant compared to lifelong therapy has considerable cost-saving implications.

Regenerative Medicine Neurology