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CANVAS Trial Results: Better For Janssen, Lilly Or the SGLT2 Class?

Executive Summary

Janssen's Invokana reduced cardiovascular events in CANVAS on par with the MACE reduction in Lilly's and Boehringer's EMPA-REG trial for competing SGLT2 inhibitor Jardiance, but the CV benefit comes with a doubling of amputation risk versus placebo.

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