AbbVie May Be Poised For An Oral RA Smack Down
Upadacitinib hit the primary endpoints in the first of six Phase III studies in rheumatoid arthritis, as well as several important secondary endpoints. Continued success in Phase III will position the candidate well in the race to market with Lilly.
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AbbVie says safety results for the JAK1 inhibitor upadacitinib in SELECT-MONOTHERAPY study were in line with the rheumatoid arthritis population, but some analysts are concerned about the drug's cardiovascular profile, especially compared with Pfizer's first-in-class Xeljanz.
More Phase III data for AbbVie's selective JAK1 inhibitor upadacitinib appear to back a potential best-in-class claim but eyes remain on safety after a death from pulmonary embolism.
AbbVie is optimistic that its JAK1 inhibitor upadacitinib and anti-IL23 candidate risankizumab can increase its autoimmune market share, doubting a thromboembolic class effect for JAK inhibitors.