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Ibrance Trial Cements CDK4/6 Inhibitors As Standard Of Care In Breast Cancer

Executive Summary

New England Journal of Medicine editorial sings the praises of CDK4/6 inhibitors in breast cancer, which include Pfizer's Ibrance, Novartis's ribociclib and Elli Lilly's abemaciclib.

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Novartis Sets 'Flexible Pricing' For Kisqali To Compete Against Pfizer's Ibrance

Novartis has packaged and priced Kisqali – the second CDK4/6 inhibitor approved in the US – to compete with Pfizer's Ibrance, which made the mechanism of action the standard of care in untreated metastatic HR+/HER2- breast cancer.

Novartis CDK4/6 Profile Boosted But Challenge To Pfizer Rival Uncertain

Novartis' Phase III MONALEESA-2 trial shows that ribociclib plus letrozole has strong efficacy and an acceptable tolerability profile for first-line advanced HR+/HER2- breast cancer patients, but analysts say the results do not surpass those of Pfizer's first-to-market Ibrance plus letrozole in a similar setting.

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