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ROCK on, ROCK off: Amakem gets €18 million to address rho kinase side-effect problem

This article was originally published in Scrip

Executive Summary

Amakem, the Belgian ophthalmology start-up spun out from Devgen early in 2010, has secured an €18 million series A financing to take its lead drug candidate to clinical proof of concept. The firm is working on a medicinal chemistry "trick" to enable it to develop drugs which inhibit Rho Kinase (ROCK) without causing the unwanted side-effects that have tended to interfere with the development of such compounds.

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