Arcellx Raises $115m To Advance Novel T-Cell Therapies
First CAR-T In Phase I, Second Construct Heading For Clinic
The company’s first candidate is a BCMA-targeting CAR-T, but Arcellx also is developing ARC T-cells controlled by a synthetic protein. Both have a binding domain that may confer better safety and efficacy than competitors.
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Idecabtagene vicleucel for fifth-line multiple myeloma lags GSK’s BCMA-targeting ADC Blenrep, but it is months ahead of J&J/Legend’s CAR-T. Abecma is BMS’s second CAR-T approval this year.
New board directors named at Eli Lilly, Immunicum, and Talaris Therapeutics.
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