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Forging Ahead In Vitiligo: Incyte’s Ruxolitinib Cream Scores Phase II Win

Executive Summary

The topical version of Jakafi will move into Phase III later this year for the autoimmune disease after a strong Phase II showing.

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Atopic Dermatitis: Ruxolitinib And Baricitinib Spearheading New Therapies

Top-line Phase III results from Incyte’s TruE-AD2 study of ruxolitinib cream and Eli Lilly’s BREEZE-AD4 and BREEZE-AD5 studies of oral baricitinib show that the compounds achieved primary endpoints in atopic dermatitis, and they may eventually challenge Sanofi’s Dupixent’s growth in the sector.

Unhappy New Year For Incyte With Itacitinib Flop

Incyte's hopes of reducing its reliance on Jakafi have suffered a blow after a Phase III trial of itacitinib failed. The stock has slumped and analysts are raising concerns about the company's ability to generate value from its hefty R&D investments.

Lilly's Latest Olumiant Data Raise Question Of JAK Inhibitor Role In Atopic Dermatitis

While the BREEZE-AD7 data show that baricitinib may effectively treat AD in combination with topical corticosteroids, a patient treated with the drug in the ex-US study had a pulmonary embolism.

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