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Genetic Approaches Look Beyond Oncogenes For Cancer Therapy Targets

This article was originally published in Start Up

Executive Summary

A half decade of large-scale cancer genome sequencing has identified only one new and relatively common druggable oncogene target. But the genes that cause out-of-control proliferation also create problems for the cancer cells, which may then need to hijack normal cellular functions to help them survive. A research team used genetic screening to find such a dependency and showed that inhibiting the process could improve treatment.

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