This article was originally published in Start Up
Cytox Ltd.'s diagnostics and research services are all based on the cell division cycle theory of Alzheimer's pathogenesis. The firm thinks its diagnostic, a blood test biomarker that measures the integrity of the cell cycle G1/S restriction point in peripheral blood lymphocytes, will detect AD in pre-symptomatic stages and that it can predict which patients suffering from mild cognitive impairment will convert to Alzheimer's. Furthermore, Cytox maintains that its lead program, a neuroblastoma assay, can screen compounds for their potential to affect Alzheimer's disease.
You may also be interested in...
A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Looking Forward to Pharma's Decade of Predictive Efficacy," features profiles of Champions Biotechnology, Cytox, Immuneering and Rhenovia. Plus these Start-Ups Across Health Care: Freedom Meditech, MedShape Solutions, Molteni Therapeutics and TARIS Biomedical.
Champions Biotechnology Inc.'s preclinical screening technology uses xenografts that it creates by implanting primary human cancer tumors into immune-deficient mice. The tumor cells are never passaged in cell tissue culture and therefore maintain the fundamental genotypic features of the original cancer because the risk of mutations through successive generations in culture is eliminated. The company has signed preclinical screening deals with a number of partners and it's also building its own therapeutic pipeline.
Rhenovia Pharma SAS believes it can help companies looking to improve existing Alzheimer's disease therapies by using computational models of the brain to identify chemical combinations capable of positively impacting disease symptoms. The start-up aims to build a service-based business running its specialized "biosimulations" on compounds that other companies currently market, have in development or have previously rejected for lack of efficacy.