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Plexxikon Inc.

This article was originally published in Start Up

Executive Summary

Plexxikon begins the drug discovery process by identifying lead molecules that loosely fit those protein folds, or domains, that are conserved among druggable protein families. These molecular scaffolds may serve repeatedly as a template for designing new chemical entities against a variety of druggable targets within that family. As the number of scaffolds and structural information about them increases, the efficiency of selecting the appropriate one for a given drug target should improve, reducing the time from a hit to an optimized drug lead.

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