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Merck halts vorapaxar Phase III trial in ACS patients, amends TRA-2P Phase III trial

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Executive Summary

Merck has announced major changes to two Phase III clinical studies of vorapaxar, an investigational cardiovascular focused therapeutic candidate that it acquired through the acquisition of Schering-Plough, following a review by a combined data safety and monitoring board. As a result of the safety and efficacy review, the company is discontinuing the TRACER study in patients with acute coronary syndrome (ACS) while the TRA-2P study, which is evaluating the compound in secondary prevention of heart attacks will only continue in a narrower patient population.

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