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Fate of Avastin in early-stage cancer uncertain after second Phase III failure in colon cancer

This article was originally published in Scrip

Executive Summary

Roche is facing further disappointment with its top selling drug, Avastin (bevacizumab) – which is so far approved for advanced/metastatic cancer in a number of tumour types – after the anti-angiogenic agent failed in its second Phase III trial in early-stage colon cancer to reduce the risk of disease recurrence. Meanwhile, the FDA has delayed its much-anticipated decision on Avastin's use in metastatic breast cancer after the company submitted new information.

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