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Repros discontinues highest dose of Proellex in endometriosis trial

This article was originally published in Scrip

Executive Summary

Repros Therapeutics is discontinuing the 50mg dose of its endometriosis candidate, Proellex (CDB-4124), in a Phase II trial, because it lacks therapeutic differentiation from the lower doses of the drug. The 50mg dose was also found to elevate liver enzymes – an indication of toxicity - in a subset of women in the trial who had endometriosis-associated anaemia.

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