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Acetaminophen glutathione deficiency link merits warning for HIV-infected -- petition.

This article was originally published in The Tan Sheet

Executive Summary

ACETAMINOPHEN AND GLUTATHIONE DEFICIENCY: HIV PATIENTS SHOULD BE WARNED through labeling about use and overuse of acetaminophen because the drug tends to deplete glutathione (GSH) and is "potentially more toxic to GSH-deficient individuals," Stanford University School of Medicine researcher Leonore Herzenberg and AIDS Treatment News publisher John James maintain in a Feb. 14 citizen petition to FDA. They note that a "series of studies over the last six years has demonstrated that a pronounced glutathione deficiency is frequent in HIV-infected adults and children and tends to become more pronounced as HIV disease progresses."





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