In Vivo summarizes the technologies of several recently founded companies: Ardais Corp., is creating information products from consolidating high-quality, reliable biological samples and related information for use in drug discovery and development. BeneCor Heart Systems was founded in September 1999 to develop and commercialize a totally implantable, permanent heart replacement device. Chronix Biomedical will focus on the diagnosis and management of chronic diseases by detecting what it calls "reshuffled genes," the detours the human genome map takes when confronted with viruses or other toxins. Founded in July 1999 by a group of former Columbia University physicians and scientists, MediData Solutions Inc. will offer new software and technology for managing clinical trials. Spiration is developing devices to treat pulmonary diseases, in particular chronic obstructive pulmonary disease (COPD), for which no cure exists.