Sanofi kills PhIII JAK2 inhibitor on safety grounds
This article was originally published in Scrip
Executive Summary
Sanofi has called an immediate halt to all trials of fedratinib (SAR302503) following reports of neurological side-effects. The company had reported positive Phase III results for the JAK2 inhibitor in myelofibrosis earlier this year. Now, however, it says it is cancelling all plans for regulatory filings.
You may also be interested in...
BMS Buoyed By EU Approval Of Myelofibrosis Drug
There have been lots of twists and turns on the development path for Inrebic which is now the second JAK inhibitor to be approved in the EU for MF since the blockbuster Jakavi was cleared in 2012.
Inrebic Approval Is A Boost For Myelofibrosis And Celgene's Buyer Bristol
Investors in Impact Biosciences, which sold the selective JAK2 inhibitor to Celgene for $1.1bn up front, could double their money with milestone fees based on fedratinib's approval.
Keeping Track: Accelerated Approval For Tecentriq And A Burst Of Filings And Submissions
The latest drug development news and highlights from our US FDA Performance Tracker.