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Tempo Pharmaceuticals Inc.

This article was originally published in Start Up

Executive Summary

Tempo Pharmaceuticals produces nano-sized therapeutics designed to deliver a one-two punch: the targeted and sequential release of two drugs at a specific location in the body. Though the technology offers an improved way to deliver drugs, especially highly toxic chemotherapeutics to treat cancer, the company shies away from the drug delivery label. The company says its technology isn't just about getting drug into a tumor; it's about getting the right drug to the right location at the right time to address the microenvironment of the disease.

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Start-Up Previews (04/2008)

A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Nanotechnology, a Balm for the Challenges of Drug Delivery," features profiles of BIND Biosciences, Liquidia Technologies, Nanolymf, Tempo Pharmaceuticals, and TransGenex Nanobiotech. Plus these Start-Ups Across Health Care: Breathe Technologies, Crospon, and InterMed Discovery.

TransGenex Nanobiotech Inc.

TransGenex Nanobiotech is taking a multi-pronged approach to building a nanotechnology company. In the short term, the company is generating revenue from sales of its custom nanoparticles and its Nanogene reagents that can be used to deliver genes to cells. It is also using its technology to develop diagnostic platforms, especially for lung and ovarian cancer. Finally, TransGenex plans to develop its own novel drug candidates. It's focusing first on products with anti-inflammatory properties, which could find application in asthma as well as several cancers.

BIND Biosciences Inc.

BIND Biosciences generates nanoparticles with unique targeting agents that allow them to home in on cancerous cells with deadly precision. Because it's impossible to mathematically design the optimal particle, BIND scientists have created large combinatorial libraries of nanoparticles with different biophysical and chemical properties.

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