Endothelial Dysfunction: A Drug Opportunity as Big as All Heart Disease
This article was originally published in Start Up
Executive Summary
Less than 50% of coronary artery disease is attributable to the known risk factors-such as smoking, obesity, diabetes, family history of heart disease, and high cholesterol. That's why researchers and companies are beginning to take a close look at endothelial dysfunction, a disorder of the lining of the arteries that causes vessels to fail to expand normally in response to increased blood flow. Endothelial dysfunction is widely recognized in the clinical community as the earliest detectable harbinger of heart disease, one that would help physicians address patients before they have their first heart attack or stroke. But even more than that, many now see the disorder as a reversible condition that should be treated in its own right, to avoid the future deadly consequences of chronic inflammation, clot formation, plaque deposition, or plaque rupture. Because it's still early days for the field, Endomatrix Inc. has chosen a combination nutraceutical/pharmaceutical development path. It is getting early clinical experience in patients by testing and commercializing a proprietary dietary supplement, while at the same time developing new drugs that target endothelial dysfunction.
You may also be interested in...
ProtAffin Biotechnologie AG
ProtAffin Biotechnologie AG's technology is based on the interactions between pro-inflammatory proteins such as chemokines, and leucocytes and endothelial cells that drive many acute and chronic inflammatory processes such as ischemia/reperfusion injury and rheumatoid arthritis. The company's CellJammer platform uses structural bioinformatics and rational protein engineering to take a target protein agonist that naturally binds to a GAG ligand and to create an antagonist that binds with higher affinity and blocks the target protein-GAG interaction.
Endothelix Inc.
Endothelial dysfunction (ED) is widely recognized as the earliest possible warning sign of impending heart disease, but the invasive and complex technologies for measuring it are found only cardiovascular research labs. Endothelix Inc. hopes to integrate ED measurement and monitoring into routine clinical practice with a non-invasive, non-imaging, point-of-care screening tool for the general population.
Endothelix Inc.
Endothelial dysfunction (ED) is widely recognized as the earliest possible warning sign of impending heart disease, but the invasive and complex technologies for measuring it are found only cardiovascular research labs. Endothelix Inc. hopes to integrate ED measurement and monitoring into routine clinical practice with a non-invasive, non-imaging, point-of-care screening tool for the general population.