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Aureon Biosciences

This article was originally published in Start Up

Executive Summary

The importance of tissue analysis in diagnosing and characterizing disease, notably cancer, can't be underestimated. But analysis of tissue as a source of predictive medical information has been slow to evolve. Aureon Biosciences is changing this situation by developing a new tissue analysis platform to create predictive tests that oncologists can use to guide selection of cancer treatments.

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Personalized medicine is a field as vast as the differences between individuals, and encompasses technologies, markets, and treatment strategies ranging from autologous cancer vaccines to molecular diagnostics and gene-targeted drugs to methods for visualizing subtle differences in tissues--the foci of the three companies profiled herein.

Vysis's Ship Comes In

Not too long ago, Vysis was just one of dozens of struggling genomic start-ups. Now, however, with its pending acquisition by Abbott Laboratories, it is a poster child for genomics success. Abbott is betting on the potential of Vysis's core position in fluorescent in situ hybridization (FISH) as a diagnostic tool, which allows users to evaluate disease based on changes at the chromosomal level. Abbott has been marketing Vysis's FISH test for the HER2 gene and since this summer.

Vysis Preps For Prime Time

Tiny Vysis scored big this spring, winning the backing of two major therapeutic and diagnostic companies for its products. But is its core technology ready for prime time? Vysis sees an opportunity to expand use of its FISH diagnostics technology beyond niche applications in the clinical market. But skeptics say the technology is too complex and expensive for routine clinical use.

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