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Focus on Bioinformatics

This article was originally published in Start Up

Executive Summary

Because of the difficulty in combining knowledge of both biology and informatics in one company, the new bioinformatics start-ups reckon they can build a new service business for biotechs and for Big Pharma.

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Structural Bioinformatics

Drug Discovery Tools; Bioinformatics. Structural Bioinformatics performs computational high-throughput screening with a 4-D approach to the generation of protein structures, that is, dynamic 3-D protein structures viewed through the fourth dimensionof time. It seeks to bridge the gap between novel gene-sequence data generated by genomic researchers and the 3-D structural information used by researchers in drug discovery.

Genomica Corp.

Drug Discovery Tools; Bioinformatics. Genomica is building a series of products that support computer-aided gene analysis with input from a variety of sources, including linkage analysis, mapping, sequencing and functional analysis. Its initial product, {The Genome Typographer} incorporates algorithms that facilitate fast and sensitive searches of long DNA sequences, incorporates a genomic repository, a reference database and semantic mappers which conduct automatic queries for public databases.

Molecular Informatics

Drug Discovery Tools; Bioinformatics. Molecular Informatics designs software that manages and integrates on an enterprise-wide basis genomic data for laboratories working on large-scale DNA sequencing. {BioMerge} is an advanced relational database technology geared to storage, retrieval and analysis of genetic information. {BioLIMS} was developed with Applied Biosystems (division of Perkin Elmer) and is being built into ABI's {Prism} series of DNA sequencing instruments.

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