Cardiff Oncology Falls Despite Onvansertib’s Broad Potential In KRAS-Mutant CRC
Phase II Trial To Initiate In Q4; Data In 2024
A planned Phase II trial for PLK1 inhibitor onvansertib in KRAS-mutant colorectal cancer may support accelerated approval, but results are two years off and the company cut its prostate cancer plans to conserve cash.
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Lumakras data at ESMO in KRAS G12C-mutated lung cancer bested docetaxel on PFS, and largely on safety. OS was better for chemotherapy, but the trial was not powered for statistical significance on OS.
The company is reporting strong ORR, durability and PFS at ESMO in heavily pretreated colorectal cancer, an indication where Amgen’s Lumakras has struggled.
The companies published data showing the drug was effective in patients with both homologous recombinant repair mutated and non-mutated disease.