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Amgen NSCLC Data Could Give Lumakras Boost As Competition Looms

Executive Summary

Mirati’s adagrasib is expected to win an FDA lung cancer nod, while also showing better data in pancreatic and colorectal cancer, making it more important for Lumakras to show strength in NSCLC.

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Combinations Key For Amgen’s Lumakras, But PD-1/L1 Data Held Until August

A World Conference on Lung Cancer abstract shows responses to Lumakras with a SHP2 inhibitor but closely watched results for anti-PD-1/L1 combinations are under embargo until the meeting next month.

US FDA Puts Mirati’s KRAS Challenge To Amgen In The Slow Lane

The US regulator will review adagrasib on standard timelines, leaving some investors anxious about Mirati’s efforts to rival Amgen’s Lumakras.

Amgen’s Lumakras Falls Short Of Mirati’s Adagrasib In Pancreatic Cancer

The firm’s first-in-class KRAS inhibitor has shown lower objective response rates than Mirati’s rival candidate in a Phase I/II pancreatic cancer study, but experts note that its lung cancer opportunity, where Amgen can build up a considerable lead, is larger.

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