Mirati Spies ‘First-In-Class’ Chance For KRAS Inhibitor In Pancreatic Cancer
Adds To Colorectal Cancer Opportunity
While chasing Amgen’s Lumakras in NSCLC, Mirati looks to now have an edge in two other tumor types.
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With Vida Ventures and Leaps by Bayer leading the round, Affini-T raises $175m to advance its KRAS-targeted T-cell therapies into the clinic and add technological capabilities.
The firm’s first-in-class KRAS inhibitor has shown lower objective response rates than Mirati’s rival candidate in a Phase I/II pancreatic cancer study, but experts note that its lung cancer opportunity, where Amgen can build up a considerable lead, is larger.
Bayer is handing back rights to two early-stage off-the-shelf CAR-Ts to Atara, but the split could still be good news for the biotech company.