Chinese Biotech Bets On Intravenous 3CL Antiviral Contender For COVID-19
While new oral COVID-19 drugs are commanding the headlines, a little-known Chinese biotech is pushing ahead with an intravenous small molecule antiviral candidate now moving towards Phase II/III US trials, its CEO tells Scrip.
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China’s Home-Grown Oral COVID Antiviral Eyes Wider Population
Simcere is weighing options for SIM0417 in a Phase I trial in China as the first major domestically-developed potential rival to Pfizer’s oral COVID-19 antiviral Paxlovid. The study is likely to include wider patient groups ranging from those without symptoms to severe patients.
Domestic Firms Play Oral Antiviral Catchup As China Approves Paxlovid
With home-grown 3CL protease inhibitors for COVID-19 still shrouded in uncertainty, some companies in China are now turning to oral RNA polymerase inhibitors as a nearer term option for both mild-to-moderate and severe patients.
Coronavirus Update: More Approval, Trial Progress For Non-Vaccine Options
Multiple non-vaccine options for COVID-19 continue to progress, with promising new clinical results for Sorrento's small molecule drug and a supplementary approval in Japan for Chugai's antibody combo. Meanwhile, China's CRDC has in-licensed technology for Ligand to apply to an oral antiviral it is developing. Meanwhile, SK Biosciences' novel nanoparticle vaccine is positive in early trials.