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Theravance To Slash Headcount By 75% After Latest Clinical Trial Setback

Executive Summary

The Phase III failure of ampreloxetine in nOH followed disappointing Phase IIb data for izencitinib in ulcerative colitis in August. Theravance narrows focus to respiratory disease, including label expansions for Yupelri.

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Theravance's Gut-Selective JAK Inhibitor Disappoints In Ulcerative Colitis Study

Top-line results from a Phase IIb study of Theravance’s potential gut-selective JAK inhibitor izencitinib have not matched expectations, and results from a similar early-stage study in Crohn’s disease with the Janssen-partnered candidate are now awaited at the end of the year or in early 2022.

Mylan/Theravance’s Yupelri Will Launch Late This Year To Address COPD Niche

Yupelri was approved by the US FDA as the first nebulized long-acting muscarinic antagonist for once-daily treatment of chronic obstructive pulmonary disease.

Theravance Banks $100m As J&J Bets Big On IBD Drug

If the JAK inhibitor codenamed TD-1473 proves effective in Crohn’s disease and ulcerative colitis, the clinical, regulatory and commercial know-how in IBD from partner Janssen could help Theravance pocket $1bn.

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