Second Cellectis CAR-T Therapy On Clinical Hold, Dosing Could Be Issue
A Phase I study for allogeneic therapy UCARTCS1A was put on clinical hold after a patient died. High dosing and double exposure to cyclophosphamide pre-conditioning may have played a role.
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The gap between potential approvals for Bristol’s ide-cel and Janssen’s JNJ-4528 has narrowed as both CAR-T therapies show high response rates in multiple myeloma – and as bispecific antibodies, including Janssen’s teclistamab, edge into the space.
"Not as good as TALEN," was Cellectis's verdict on CRISPR gene editing, and it appears Pfizer concurs. The big pharma has licensed Cellectis's lead TALEN (not CRISPR) gene-edited CAR-T product candidate UCART19. Servier held an option on the rights, but exercised it early and handed it straight over to Pfizer.
Servier has signed a strategic collaboration agreement with Cellectis to develop and commercialize up to six cancer products in a deal potentially worth $850m.