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Roche Notches Big IO Win With Tecentriq/Avastin Combo In First-Line HCC

Executive Summary

Following quickly on a Bristol trial failure with Opdivo in first-line HCC, Roche’s PD-L1 inhibitor looks poised to be the first immunotherapy approved in the setting, with plans for US, EU and China filings.

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Narrow HCC CheckMate-459 Miss For Opdivo Points The Way For Combos, Roche Shows How

Full data at ESMO show Opdivo managed to scrape a tolerability edge over standard-of-care sorafenib in liver cancer, but eyes were drawn to Roche’s early study of Tecentriq/Avastin as the way forward in this difficult-to-treat cancer.

BMS' Bid For Opdivo In First-Line HCC Stymied

Top-line results from a Phase III study testing Opdivo versus Nexavar in first-line liver cancer fail to meet OS target. Bristol points to positive numerical trend, but the results are a setback in the indication.

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