Wider Than AZ’s PACIFIC – Novartis Has Broad NSCLC Plans For Canakinumab
Novartis is taking its unexpected CANTOS cancer findings for canakinumab and running with them to Phase III in an adjuvant lung cancer setting that is broader that AstraZeneca's PACIFIC study.
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Novartis immunology chief Eric Hughes tells Scrip a wealth of data is showing that early treatment with Cosentyx can prevent the structural changes that lead to lack of mobility in ankylosing spondylitis and psoriatic arthritis patients.
New products submitted for evaluation by the European Medicines Agency include Pfizer’s lorlatinib for lung cancer, Teva’s fremanezumab for migraine, and Shionogi’s lusutrombopag for thrombocytopenia. An already authorized drug, Novartis’s canakinumab, has been filed for a new use: reduction of cardiovascular risk.
New CANTOS analyses show that the "lower is better" mantra applies to inflammation as well as LDL-cholesterol. Novartis hopes they will lead canakinumab to becoming the first targeted anti-inflammatory therapy for heart attack patients, but hurdles lie ahead.