Merck's Keytruda Claims Market Leadership In First-line Lung Cancer
Merck enjoyed a good second quarter, beating sales expectations for Keytruda and other drugs, which helped offset losses related to patent expirations.
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Merck To Build Case For Doravirine-Based HIV Products On Efficacy, Safety Differences
Merck adds to its stagnating HIV portfolio with US approvals of doravirine and a three-drug combo including the NNRTI, but the combo’s potential may be limited due to inclusion of an older version of tenofovir.
Merck's Keytruda Enjoys Clean Sweep In Lung Cancer, At Bristol's Expense
Merck came out ahead in the immuno-oncology combination showdown at AACR, with a strong overall survival benefit for Keytruda/chemo in the Phase III KEYNOTE-189 study in first-line NSCLC. The data were seen as practice-changing, but Bristol's CheckMate-227 trial of Opdivo/Yervoy failed to impress in the same way.
Bristol Debuts Opdivo/Yervoy Data In New First-Line Lung Cancer Bid
The pharma hopes showing a PFS benefit in first-line NSCLC patients with a high tumor mutation burden may provide a way to compete with Merck in that setting, but analysts think it will need overall survival data.