Opdivo Success In Early Melanoma Paves Way For Other Tumor Types
Study finds that Bristol-Myers Squibb's PD-1 inhibitor Opdivo beats the company's CTLA-4 inhibitor Yervoy in Stage III/C or Stage IV melanoma, spurring hopes for ongoing studies in other tumor types.
You may also be interested in...
The recently launched Opdivo/Yervoy combination already has a leading position in first-line kidney cancer in the US – with a 30% share of new patients – but has been rejected in Europe.
New FDA labeling brings Tafinlar/Mekinist into adjuvant melanoma setting, but Bristol's competing Opdivo already has captured nearly 50% of the market and is approved regardless of genetic mutation.
I-SPY2 study shows promising efficacy for PD-1 inhibitor Keytruda in combination with chemo in high-risk breast cancer – including a tripling of response rate in triple-negative breast cancer – but also raises red flag on immune-mediated adverse events in early-stage patients.