Game Changer: Merck's Stealth Keytruda-Chemo Filing Stirs NSCLC Market Dynamics
Merck & Co. has stealthily filed its highly anticipated Keytruda plus chemotherapy combination for first-line treatment of non-small cell lung cancer on the back of Phase II data, months earlier than expected and before the completion of a Phase III study.
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AACR In Review: IDO Pushes Ahead, CTLA-4 Combo Lags Behind
Though momentum is building for IDO/PD-1 combos, it's still early days for new immunotherapy programs. Clinicians and investors weigh in on the latest data from the American Association for Cancer Research meeting and the state of the immuno-oncology field.
Pfizer Takes Step Back With Avelumab, Step Forward On CAR-T
Major changes to Phase III Lung 100 study of PD-L1 inhibitor avelumab mean a big delay for development in first-line lung cancer, but, separately, Pfizer advances in allogeneic CAR-T therapy with partners Servier and Cellectis.
Merck's Keytruda Reaches Blockbuster Status, But Still Lags In Lung Cancer
Merck’s PD-1 inhibitor Keytruda brought in $1.4bn in 2016 and appears poised to take advantage of first-mover status among immuno-oncology agents in first-line NSCLC.