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Amgen's Kyprolis Miss In First-Line Myeloma Surprising, But Clinically Irrelevant

Executive Summary

Because CLARION was designed to test Kyprolis head-to-head against fellow proteasome inhibitor Velcade, the failure could hurt the drug's standing in its class. But the trial design used a regimen largely phased out of clinical practice and Amgen has other chances to prove superiority.

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