True North Therapeutics Inc.
Selectively inhibiting the complement system
This article was originally published in Start Up
Executive Summary
True North Therapeutics Inc. aims to develop a monoclonal antibody that acts as a complement inhibitor to shut down a key actor of the innate immune system known as the complement system. True North believes its preclinical candidate will work early in the complement pathway and be selective to C1s, thus shutting down only the “classic” complement pathway activated by antigen-antibody (immune) complexes.
You may also be interested in...
Strategic Spin-Outs: Biotechs Structure Their Progeny For Success
Placing assets in new companies is a growing trend for biotech start-ups; freed to evolve differently, spin-outs are structured to increase exit options and maximize investor returns. We profile Envisia Therapeutics, F-star Alpha, Onkaido Therapeutics, Seragon Pharmaceuticals, and True North Therapeutics.
Super-Specialist CROs: Commercializing Pharma R&D Expertise
Outsourcing is not just for mundane pharma services anymore. Increasingly, drugmakers are contracting for specialized R&D assistance they expect to provide strategic as well as tactical advantages.
Spero Therapeutics: Remodeling Antibiotics
Like other companies investigating entirely new ways of treating bacterial infections, biotech start-up Spero is increasingly aware that novel antibiotics may need to travel new clinical and regulatory pathways to market.