Scrip is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Protagonist Therapeutics Inc.

Discovering oral anti-inflammatory peptide therapeutics

This article was originally published in Start Up

Executive Summary

It takes one to know one. That’s the road that Protagonist Therapeutics Inc. has taken in forging alliances with other small companies focused on developing peptide therapeutics, instead of taking the more conventional step of signing a Big Pharma partner. Protagonist has found that smaller firms understand the value of its platform and what it can deliver. Protagonist’s platform revolves around disulfide-rich peptides, a specific subclass of peptides whose molecular structure makes them unusually stable. That characteristic lowers their susceptibility to enzymatic degradation and therefore boosts the potential that they can become oral drugs. Advocates see DRPs as combining the best aspects of both proteins and small molecules: physically large enough to suitably cover the surfaces of important molecular targets now bound only by injectable proteins, yet small enough to have pharmacokinetic properties similar to small molecules.

You may also be interested in...

Super-Specialist CROs: Commercializing Pharma R&D Expertise

Outsourcing is not just for mundane pharma services anymore. Increasingly, drugmakers are contracting for specialized R&D assistance they expect to provide strategic as well as tactical advantages.

Spero Therapeutics: Remodeling Antibiotics

Like other companies investigating entirely new ways of treating bacterial infections, biotech start-up Spero is increasingly aware that novel antibiotics may need to travel new clinical and regulatory pathways to market.

RxMP Therapeutics LLC

RxMP Therapeutics LLC is working to resolve excessive diffuse bleeding that is often associated with trauma, and also with certain orthopedic and cardiovascular surgeries. The start-up believes it can successfully treat excessive diffuse bleeding with particles produced from the membranes of red blood cells that have been freeze-dried and then, literally, blown to bits.


Related Companies




Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts