Scrip is part of Pharma Intelligence UK Limited

This site is operated by Pharma Intelligence UK Limited, a company registered in England and Wales with company number 13787459 whose registered office is 5 Howick Place, London SW1P 1WG. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction

Avexxin AS

Aiming to treat psoriasis, by inhibiting an intracellular enzyme

This article was originally published in Start Up

Executive Summary

Avexxin AS is betting that the novel molecular target identified by one of its co-founders will enable development of a drug capable of treating inflammatory skin diseases like psoriasis and perhaps, ultimately, more severe conditions such as rheumatoid arthritis. Its small molecule candidate is designed to block the intracellular enzyme group GIVαPLA2 to shut down the cytokine-mediated cascade that leads to production of the pro-inflammatory transcription factor nuclear factor-κB and eventually to the production of a better-known bad actor: tumor necrosis factor alpha.

You may also be interested in...



New Orals, Better Topicals Top Psoriasis Wish List

Biologics for psoriasis leapfrogged existing treatments in the last decade, greatly improving the standard of care. Although those may still see incremental improvements, the real changes for patient care may come with the introduction of new oral and topical treatments. START-UP profiles four emerging companies that are tackling this challenge: Avexxin, Cellceutix, Creabilis, and Convoy Therapeutics.

Super-Specialist CROs: Commercializing Pharma R&D Expertise

Outsourcing is not just for mundane pharma services anymore. Increasingly, drugmakers are contracting for specialized R&D assistance they expect to provide strategic as well as tactical advantages.

Spero Therapeutics: Remodeling Antibiotics

Like other companies investigating entirely new ways of treating bacterial infections, biotech start-up Spero is increasingly aware that novel antibiotics may need to travel new clinical and regulatory pathways to market.

Topics

Related Companies

Related Deals

Latest News
See All
UsernamePublicRestriction

Register

SC092373

Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Thank you for submitting your question. We will respond to you within 2 business days. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel