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A New Receptor-Binding Role For MicroRNAs In Cancer

This article was originally published in Start Up

Executive Summary

A research team has identified a new role for microRNAs, the small pieces of noncoding RNA that can influence gene expression. They show that miRNAs generated in solid tumors will infiltrate into nearby cells, binding with a toll-like receptor and promoting chronic inflammation – a hallmark of the spread of many solid tumors. The researchers believe they will be able to identify a drug target and small molecules that can block the miRNA-TLR binding interaction, offering up a novel treatment strategy for cancer and possibly other diseases characterized by chronic inflammation.






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