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New Findings About The Ketamine Effect And Treating Depression

This article was originally published in Start Up

Executive Summary

Research has now revealed the mechanism underlying the anesthetic ketamine's rapid and sustained antidepressant effect: it activates an important signaling pathway in the prefrontal cortex of the brain. The findings provide clues that could lead to faster-acting drugs for depression or potentially even the adoption of current drugs for this use or augmentation of the effects of existing antidepressants.

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Forest’s acquisition of Clinical Data to get its just-approved antidepressant signals continuing strong demand. But better, and much needed, treatments remain elusive. We profile four emerging antidepressant drug developers in this issue: Euthymics Biosciences, Naurex and PharmaNeuroBoost.

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