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Sorbent Therapeutics Inc.

This article was originally published in Start Up

Executive Summary

Formed by a cadre of veterans from Baxter Healthcare’s renal division, Sorbent Therapeutics Inc. is developing polymer drugs that treat disease through the management of sodium and fluid volume in the body. Those two factors, along with potassium reduction or retention depending upon the condition, are keys to addressing a string of related illnesses including end-stage renal disease and congestive heart failure. Sorbent’s polymer drugs remove sodium from the gastrointestinal tract but are not absorbed into the rest of the bloodstream, thereby minimizing any number of potential toxicity, bioavailability and metabolism risks.

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A preview of the emerging health care companies profiled in the current issue of Start-Up. This month's profile group, "Despite Challenges, Congestive Heart Failure Draws A Crowd," features profiles of miRagen, NellOne Therapeutics, Phrixus Pharmaceuticals and Sorbent Therapeutics. Plus these Start-Ups Across Health Care: Ambicare, Anulex Technologies, NeoTract and Sistemic.

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Phrixus Pharmaceuticals Inc. aims to repurpose a compound that may be able to boost the blood-pumping capacity of damaged hearts. Carmeseal was originally developed in the 1950s by BASF as a surfactant called poloxamer-188. If results seen in several animal cardiovascular models can be reproduced in humans, Phrixus’ compound could become an emergency room treatment for acute decompensated heart failure.

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