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Ocelus Ltd.

This article was originally published in Start Up

Executive Summary

Ocelus Ltd. hopes to extend transdermal delivery to macromolecules. Its early-stage technology combines a microchip reservoir with microneedles that could painlessly inject precise yet tiny amounts of a drug into the skin at hundreds of sites per square centimeter. This could make administration simpler, and by reducing the pain associated with injectable drugs, improve patient compliance.

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Transdermal Drug Delivery: More Than Skin Deep

Start-ups continue to seize opportunities for delivering new and existing drugs transdermally. They are also poised to capitalize on next-generation technologies for delivering macromolecules through the skin. In this issue, we profile AllTranz, Ocelus, Quinnova Pharmaceuticals and Syntropharma.

AllTranz Inc.

AllTranz Inc. has technology suitable for making pro-drugs out of opioids and cannabinoids, and it thinks these can be developed as treatments for a wide range of indications, from neuropathic pain to addiction, pancreatitis, and more. The company is leading, however, with a gel formulation that combines cannabidiol and penetration enhancers to treat the pain of osteoarthritis as well as strains and sprains.

Quinnova Pharmaceuticals Inc.

Quinnova Pharmaceuticals Inc.'s Proderm Technology delivery system is a water-lipid-based formulation designed to apply active ingredients to the skin for the treatment of inflammatory skin diseases. Several Proderm products are already on the market. The start-up's TwinDerm technology - a two-step, single-unit topical system that allows delivery of two products in sequence from a single pouch - is designed to make treatment simpler and more convenient, therefore improving patient compliance.

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