Scrip is part of Pharma Intelligence UK Limited

This site is operated by Pharma Intelligence UK Limited, a company registered in England and Wales with company number 13787459 whose registered office is 5 Howick Place, London SW1P 1WG. The Pharma Intelligence group is owned by Caerus Topco S.à r.l. and all copyright resides with the group.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By

UsernamePublicRestriction

Where Are They Now? Checking In On Four Cardiovascular Start-Ups

This article was originally published in Start Up

Executive Summary

It's no secret increasing generic competition and regulatory oversight, combined with the financial challenges of developing a primary care drug, make cardiovascular a tough place for venture-backed biotechs. START-UP takes the pulse of four previously profiled cardiovascular companies -- arca Biopharma, Celladon, NovaCardia and Portola Pharmaceuticals, -- to see what lessons they've learned.

You may also be interested in...



Protein Rescues Function After Heart Failure

Impaired calcium uptake is a hallmark of heart failure. The enzyme SERCA2a is known to play a critical role in maintaining the normal contractile function of those cells whose activity is decreased or disrupted in failing hearts. But its large size makes the enzyme a difficult drug target. Now, however, a research team has identified a small protein that interacts with SERCA2a after heart failure, which could open the door on a potential new approach to therapy.

Protein Rescues Function After Heart Failure

Impaired calcium uptake is a hallmark of heart failure. The enzyme SERCA2a is known to play a critical role in maintaining the normal contractile function of those cells whose activity is decreased or disrupted in failing hearts. But its large size makes the enzyme a difficult drug target. Now, however, a research team has identified a small protein that interacts with SERCA2a after heart failure, which could open the door on a potential new approach to therapy.

Despite Recent Setbacks, Merck's CV Pipeline Is Strong

The Big Pharma reports better than expected first quarter revenues and discusses what is coming in R&D and the cardiovascular pipeline.

Related Content

Topics

Related Companies

Related Deals

Latest Headlines
See All
UsernamePublicRestriction

Register

SC091904

Ask The Analyst

Ask the Analyst is free for subscribers.  Submit your question and one of our analysts will be in touch.

Thank you for submitting your question. We will respond to you within 2 business days. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts

Cancel