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GSK/Pentraxin: Targeting SAP in Amyloidosis, and Maybe Alzheimer's Too

This article was originally published in Start Up

Executive Summary

University College London spin-out Pentraxin's February 2009 tie-up with GlaxoSmithKline in amyloidosis showed GSK's willingness to invest in risky, early-stage research. Weeks later, Pentraxin announced promising clinical data with a related program in Alzheimer's, raising the possibility that this alliance may yet expand beyond a specialist niche.

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Max Planck Innovation Launches Early-Stage Fund

Frustrated by the continued lack of early-stage VC funding for projects emerging from its laboratories, Max Planck Innovations GMBH is launching its own VC fund, DDC Ventures. The fund is just one component of an ambitious tech transfer initiative dubbed the "drug development center", which kicked off last year with the creation of a Lead Discovery Center in Dortmund, Germany.

Max Planck Innovation Launches Early-Stage Fund

Frustrated by the continued lack of early-stage VC funding for projects emerging from its laboratories, Max Planck Innovations GMBH is launching its own VC fund, DDC Ventures. The fund is just one component of an ambitious tech transfer initiative dubbed the "drug development center", which kicked off last year with the creation of a Lead Discovery Center in Dortmund, Germany.

Pharmaceutical/Biotechnology Deal Statistics Quarterly, Q1 2009

Highlights from the Q1 2009 review of pharmaceutical and biotechnology dealmaking: With 57 transactions raising $1.09 billion, financing activity for Q1 2009 showed a 137% increase over Q4 2008's total. The largest deal was an initial public offering--Bristol-Myers Squibb Co. sold off 15% of Mead Johnson Nutrition Co. for $684 million-the first since Bioheart Inc.'s February 2008 IPO. In M&A, Big Pharma mega-mergers was the big story as two major players--Wyeth and Schering-Plough--were scooped up by Pfizer Inc. and Merck & Co. Inc., respectively, in deals together valued at $109 billion, making up 96% of the Q1 M&A dollar volume. Biopharma alliances-with a 25% decrease in number of deals--only reached about half the dollar volume of Q4 2008, but Bristol-Myers Squibb continued its strong performance along with several other Big Pharma players that joined the playing field; GlaxoSmithKline PLC and Novartis AG, each with five alliances, tied as the quarter's most active deal makers. Much of the fourth quarter's alliance activity followed an option-based deal structure with the biotech handling R&D through pre-proof-of-concept after which the Big Pharma partner then takes over later-stage development and commercialization.

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