Scrip is part of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Akebia Therapeutics Inc.

This article was originally published in Start Up

Executive Summary

Akebia Therapeutics believes that the shorter circulating half-life of its oral daily HIF-regulating compound, currently in Phase I trials, will keep it from over-stimulating EPO production, which is related to the cardiovascular and other safety issues faced by current injectable ESAs. Beyond its efforts with HIF and anemia, Akebia is also pursuing preclinical research on inhibitors of the human protein tyrosine phosphatase beta for vascular leakage.

You may also be interested in...

Tapping Into Top Partnering Opportunities Beyond The Blockbuster

The upcoming Therapeutic Area Partnership conference will showcase companies in niche areas that are prime targets for partnerships or acquisitions.

P&G Spinout Spins Off Another Company, While Looking To Partner Mid-Stage Oral Anemia Candidate

Akebia will sell off, partner or possibly bring AKB-6548 – thought to be a safer erythropoietin stimulator than currently available injectables – through Phase III, while its spinout, Aerpio, will focus on clinical development of candidates for diabetic macular edema and inflammatory bowel disease.

Palkion Inc.

CrystalGenomics Inc. and ProQuest Investments formed Palkion Inc. to identify and develop orally available anemia drugs that modulate the HIF prolyl hydroxylase enzyme system. Palkion is finishing up preclinical toxicology on its lead candidate for anemia associated with chronic kidney disease.

Related Content


Related Companies

Related Deals




Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts