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A New Perspective on Cancer Immunotherapy

This article was originally published in Start Up

Executive Summary

Many believe that for therapeutic cancer vaccines, a more flexible two-stage system of proof-of-principle trials followed by efficacy trials should replace the current Phase I-III structure. That's because the paradigm used for oncology drug development is based on criteria developed for cytotoxic agents, which present a very different toxicity profile, metabolism, and manner of biological and clinical response.

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