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Signaling beneath the Cell Surface

This article was originally published in Start Up

Executive Summary

Designing molecules that target protein-protein interactions in transmembrane proteins, where antibodies and fragments cannot penetrate, has been difficult. Using computational methods, a group at Penn has created novel peptides that could offer a new class of reagents for studying membrane-protein folding, assembly, and signal transduction. More broadly, they could provide access to an entire new class of targets for the design of therapeutics and drug delivery systems

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