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A New PARP-oriented Strategy for Treating Cellular Injury

This article was originally published in Start Up

Executive Summary

PARP inhibition's been hot, especially as it relates to cancer therapy: witness the Genentech-Inotek deal in September 2006. Now researchers at Johns Hopkins have described a new mechanism triggered by PARP activation that causes cell death following reperfusion injury--information that could provider drug developers with a new set of targets for treating a host of conditions.

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