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Orphan Receptor Drug Discovery

This article was originally published in Start Up

Executive Summary

In a climate favoring defined clinical product opportunities, venture capitalists have had a hard time seeing the value proposition in investing in orphan nuclear receptor drug discovery. These targets likely modulate a range of diseases, but the disease associations are undetermined. Orphan receptors are also difficult targets for drug screening. Nonetheless, a handful of start-ups are taking up the drug discovery challenge.

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