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Drug Delivery Start-ups

This article was originally published in Start Up

Executive Summary

Knowing that the competition's tougher, the new crop of drug delivery companies grows increasingly specialized.

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Carigent Therapeutics Inc.

Carigent Therapeutics' novel nanoparticle targeted drug delivery technology allows for controlled release of therapeutic agents, targeting drugs to a particular physiological site, tethering of surface ligands, and the ability to combine multiple agents--like imaging agents and drugs--into one vehicle. The foundation of the platform is an FDA-approved biocompatible and biodegradable polymer material, PLGA, which is made into particles at the nano- or micro-scale depending on the application.

Teasing Out Next-Generation Diabetes Drugs

Many start-ups are developing diabetes drugs based on known targets which could attract Big Pharma partners and get to the clinic quickly, while a few invest in novel compounds that are either riskier or address the field's smaller subsets. Among the former are Phenomix, Plexxikon, CareX and Prosidion; among the latter are DiaKine, and DiaMedica. In all cases, these companies are looking to partner with Big Pharma, which is aggressively pursuing small-molecule drugs for diabetes.

RxKinetix Inc.

RxKinetix is developing two polymer-based sustained release delivery systems. {Micronix} permits water soluble drugs, including proteins, peptides and oligonucleotides, to be blended with polymers in microparticles 1-5 microns in diameter. {ProGelz} achieves site-specific sustained release of macromolecules.

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