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Aussie Biotech Prana’s COO Diane Angus On Aging and Neurodegenerative Development In Alzheimer’s Space: An Interview With PharmAsia News (Part 1 of 2)

This article was originally published in PharmAsia News

Executive Summary

Established in 1997, Melbourne, Australia-based biotech company Prana has developed a library of chemical compounds that addresses the role of biological metals in human disease. The company's lead compound PB2 in Alzheimer's disease completed Phase IIa clinical trials, and the company recently announced a preclinical candidate for Parkinson's disease. "Prana" is Sanskrit for "moving force," or "life force," which sustains life and diminishes as humans age. The company has formed its business strategy on neurological disorders that result from interactions between selected metals and target proteins as the brain ages. COO Diane Angus sat down with PharmAsia News in Australia to talk about Prana's unique approach to developing compounds in the neurodegenerative space.

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Prana’s COO Diane Angus, Head Of Research Robert Cherny On Prana’s Unique Mechanism Of Action In Neurodegenerative Drug Development: An Interview With PharmAsia News (Part 2 of 2)

Established in 1997, Melbourne, Australia-based biotech company Prana has developed a library of chemical compounds that addresses the role of biological metals in human disease. The company's lead compound PB2 in Alzheimer's disease completed Phase IIa clinical trials, and the company recently announced a preclinical candidate for Parkinson's disease. "Prana" is Sanskrit for "moving force," or "life force," which sustains life and diminishes as humans age. The company has formed its business strategy on neurological disorders that result from interactions between selected metals and target proteins as the brain ages. COO Diane Angus and Head of Research Robert Cherny sat down with PharmAsia News in Australia to talk about Prana's unique approach to developing compounds in the neurodegenerative space.

Prana’s COO Diane Angus, Head Of Research Robert Cherny On Prana’s Unique Mechanism Of Action In Neurodegenerative Drug Development: An Interview With PharmAsia News (Part 2 of 2)

Established in 1997, Melbourne, Australia-based biotech company Prana has developed a library of chemical compounds that addresses the role of biological metals in human disease. The company's lead compound PB2 in Alzheimer's disease completed Phase IIa clinical trials, and the company recently announced a preclinical candidate for Parkinson's disease. "Prana" is Sanskrit for "moving force," or "life force," which sustains life and diminishes as humans age. The company has formed its business strategy on neurological disorders that result from interactions between selected metals and target proteins as the brain ages. COO Diane Angus and Head of Research Robert Cherny sat down with PharmAsia News in Australia to talk about Prana's unique approach to developing compounds in the neurodegenerative space.

Rethinking Alzheimer's: Mapping Out an Approval Process

Drug companies involved in Alzheimer's disease research are a little fed up with FDA. Some, like Wyeth, believe the agency should put Alzheimer's research higher up on its priority list and allow the use of surrogate endpoints for clinical trials. But FDA says that no validated surrogate exists for Alzheimer's, and until it has hard data from products in development, it is loath to recommend one. A recent reorganization of the agency's neurology group may provide an opening to press home those arguments.

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