Scrip is part of the Business Intelligence Division of Informa PLC

This site is operated by a business or businesses owned by Informa PLC and all copyright resides with them. Informa PLC’s registered office is 5 Howick Place, London SW1P 1WG. Registered in England and Wales. Number 8860726.

This copy is for your personal, non-commercial use. For high-quality copies or electronic reprints for distribution to colleagues or customers, please call +44 (0) 20 3377 3183

Printed By


Video Interview: Prothena Tackles Diseases Of Protein Accumulation

This article was originally published in Scrip

Executive Summary

Prothena President and CEO Dr. Dale Schenk briefs Mike Ward, global director of content of Informa's pharma insights portfolio, on the progress the company has made since it spun out of Elan Corp at the end of 2012. The Irish company has three antibody programs focusing on diseases associated with protein accumulation in the clinic. The lead program is NEOD001, which is a monoclonal antibody targeting the amyloid that accumulates in light chain amyloidosis. Dr. Schenk reveals that he expects to report results from the Phase IIb PRONTO trial at the end of 2017, early 2018, while the results of the pivotal Phase III VITAL study will come after that. In collaboration with Roche, the company is developing a monoclonal antibody, PRX002, that targets alpha-synuclein, a protein that has a fundamental role in the progression of Parkinson's disease and other conditions. Dr. Schenk reveals that the company has already completed one Phase I study with the molecule and is expecting to report the results of a much larger Phase I trial by the end of 2016. The third program is a monoclonal antibody, PRX003, that selectively blocks MCAM-mediated cell adhesion, which is in Phase I trials and is being developed as a treatment for psoriasis and other inflammatory conditions.






Ask The Analyst

Please Note: Click here for more information on the Ask the Analyst service.

Your question has been successfully sent to the email address below and we will get back as soon as possible. my@email.address.

All fields are required.

Please make sure all fields are completed.

Please make sure you have filled out all fields

Please make sure you have filled out all fields

Please enter a valid e-mail address

Please enter a valid Phone Number

Ask your question to our analysts